Sunday, May 20, 2018

Antibodies Against Neuropeptides

Another Nod From Nature Scientific Reports
Publications referencing use of our antibodies continue to build. We are recognized for having potent Neuropeptide Antibodies.

This most recent publication references our Guinea Pig Substance-P Antibody: Khaled Abdallah, Francis Nadeau, Francis Bergeron, Sylvie Blouin, Véronique Blais, Kelly M. Bradbury, Christine L. Lavoie, Jean-Luc Parent;, Louis Gendron. (2018). Adeno-associated virus 2/9 delivery of Cre recombinase in mouse primary afferents. Scientific Reports volume 8, Article number: 7321 (2018) doi:10.1038/s41598-018-25626-y
Figure: Distribution of the Cre-GFP in the neuronal subpopulations within the lumbar dorsal root ganglia. Representative photomicrographs showing co-localization of GFP with markers of peptidergic (Substance P), non-peptidergic (Isolectine B4) and large diameter myelinated (NF200) neurons are shown for mice (n = 6) injected in the plantar surface of both hindpaws with the AAV2/9-CBA-Cre-GFP virus. Arrows indicate neurons co-labeled for GFP and the indicated marker. Scale bars = 50 µm.
We stand behind all our products. If you are not 100% satisfied with one of our antibodies, we offer full replacements or your money back,

Thursday, May 10, 2018

Researchers Love our FBS

Potent Serum at a Great Price!
We are pleased by the 5-star ratings on our Fetal Bovine Serum (FBS). Check them out.
  • Outstanding service. Fetal bovine serum was of highest quality, easy to order and packaging and shipping were best possible.Rosemary Dziak - May 08, 2018 - Rating: 5.0
  • This is first time to buy FBS from them. Rose is very nice person. they make you easy and comfortable to purchase.jie wei - Feb 16, 2018 - Rating: 5.0
  • I enjoyed working with the people at Neuromics. The sale person was very friend and willing to take extra time to solve our problems. Product Name: FBS - (Cat#FBS001) https://www.neuromics.com/FBS001 Organization: MayoWenqian Hu - Oct 15, 2017 - Rating: 5.0
All Testimonials
FBS-500 ml-only 349 USD


Our FBS is 9CFR-tested, meeting FDA and USDA requirements. Fetal bovine serum products can also be tested to meet EMEA requirements. Note: We test each lot of FBS on our primary human cell cultures enabling us to choose lots yielding the best results...
Testimonial: "We have used the FBS from Neuromics in feeding media for primary mouse astrocytes as well as for some cell lines. Your product is good and we plan to continue using it.” - Svetlana Vidensky, MS, Senior Research Specialist in Dr. Jeffrey Rothstein lab, Department of Neurology, Johns Hopkins University Contact Rose at rose@neuromics.com or 952-374-6161 for bulk pricing.

Tuesday, May 01, 2018

Fibroblast Compression and Tumor Cells Migration

Role of Compression in Metastasis
Our Human Pancreatic Fibroblasts play a key role in this study.

Pancreatic fibroblasts are continuously gaining ground as an important component of tumor microenvironment that dynamically interact with cancer cells to promote tumor progression. In addition, these tumor-infiltrated fibroblasts can acquire an activated phenotype and produce excessive amounts of extracellular matrix creating a highly dense stroma, a situation known as desmoplasia. Maria Kalli, Panagiotis Papageorgis, Vasiliki Gkretsi, Triantafyllos Stylianopoulos. (2018). Solid Stress Facilitates Fibroblasts Activation to Promote Pancreatic Cancer Cell Migration. Annals of Biomedical Engineering. https://doi.org/10.1007/s10439-018-1997-7.

FIGURE 1. A schematic of the in vitro transmembrane pressure device. (a) Fibroblasts were grown as a monolayer on the transmembrane of a 0.4 lm transwell insert and a piston of adjustable weight was applying a compressive stress. Control cells were covered with an agarose cushion only. (b) The experimental set-up of the co-culture system consisted of fibroblasts and pancreatic cancer cells (MIA PaCa-2 or CFPAC-1) in the upper and lower chamber of a transwell insert, respectively. A piston with adjustable weight, applying 4.0 mmHg of compressive stress on fibroblasts for 48 h is shown. A co-culture system consisting of fibroblasts and cancer cells without a compressive load was used as a control.
FIGURE 2. Neuromics'  Human Pancreatic Fibroblast in culture-Controls and Compressed.


FIGURE 1. A schematic of the in vitro transmembrane pressure device. (a) Fibroblasts were grown as a monolayer on the transmembrane of a 0.4 lm transwell insert and a piston of adjustable weight was applying a compressive stress. Control cells were covered with an agarose cushion only. (b) The experimental set-up of the co-culture system consisted of fibroblasts and pancreatic cancer cells (MIA PaCa-2 or CFPAC-1) in the upper and lower chamber of a transwell insert, respectively. A piston with adjustable weight, applying 4.0 mmHg of compressive stress on fibroblasts for 48 h is shown. A co-culture system consisting of fibroblasts and cancer cells without a compressive load was used as a control.

Solid stress developed within tumors is able by itself to activate normal fibroblasts, which in turn produce excessive amounts of ECM proteins leading to desmoplasia.

Thursday, April 26, 2018

Pure and Potent Human Primary Retinal Pigment Endothelial Cells (HRPES)

Culture Ready
Neuromics is a recognized leader in providing researchers 21-CFR Compliant Primary Human Cells.

Here we feature our new Retinal Pigment Epithelial Cell (HRPES). These hard to find cells are reasonably priced and culture ready,
HRPES in Culture

Cells are provided at passage 3. HRPEs growth medium (contains 10% serum and growth supplements, Alpha-33) is recommended for cell culture and these cells have a minimum average population doubling capacity of 8 when cultured following the detailed protocol.

Thursday, April 19, 2018

ATP and Pain

P2XRs Play a Key Role
In dorsal root ganglion (DRG) neurons, ATP is an important neurotransmitter in nociceptive signaling through P2 receptors (P2Rs) such as P2X2/3R, and adenosine is also involved in anti-nociceptive signaling through adenosine A1R.

ENNPs interact with P2XRs to metabolize ATP to AMP in DRGs. Kentaro Nishida, Yuka Nomura, Kanako Kawamori, Akihiro Ohishi, Kazuki Nagasawa. ATP metabolizing enzymes ENPP1, 2 and 3 are localized in sensory neurons of rat dorsal root ganglion. European Journal of Histochemistry 2018; 62:2877.
Images: Rat DRG stained with Neuromics P2X2R and ENPP1.

Modulating ATP Processing in DRGs could prove a target for pain therapies.

Saturday, April 14, 2018

Long Term Culturing of Cells

Non-Perfusion Model
Researchers, for some studies, are demanding the ability to maintain vibrant cultures for long periods of time.

Perfusion models afford this, but are expensive, sensitive and require specialized expertise. Given this, I believed it a good time to represent a protocol that can be used for our primary neurons and can be extrapolated to many of our other primary and stem cells.

Rose Ludescher, Manager of Customer Satisfaction, is an expert in helping our customers successfully culturing cells. So if you need help with any of your cell-based assays do not hesitate to contact her. Just email your request to rose@neuromics.com.


Saturday, April 07, 2018

National Eye Institute's 3-D ROC Challenge

Are you Ready?
Neuromics is a proud Sponsor of this challenge. It enables us to further leverage our potent, proven and published 3-D Cell-Based Assay Solutions into drug discovery for eye-related diseases.

Our solution set includes 21-CFR Compliant human primary and stem cells and research ready custom and off the shelf 3-D Models. We also provide defined media and supplements.
Neuromics 3-D Blood-Brain Barrier Model
In addition to models, we offer: ECMS
•Engineered hydrogels optimized for cell types
•Coming soon: Bio-Inks for 3-D Printing-Engineered for Cells
•Nanofibers

Neuromics’ HUVECS in an engineered ECM
For all participants we offer We offer a 10% discount on all cells, 3-D models, media and supplements Contacts: Pete Shuster, pshuster@neuromics.com, 612-801-1007; Rose Ludescher, rose@neuromics.com, 866-350-1500

Thursday, March 29, 2018

Unmasking Root Causes of Stress/Anxiety

i-Fect Knocks Down Suspected Stress/Anxiety Receptor
The molecular pathogenesis underlying anxiety disorders is still unclear. Here, the authors demonstrate that myristoylated alanine-rich C-kinase substrate like 1 (MARCKSL1) overexpression in mice increases spine formation in the amygdala and induces stress hormone upregulation and anxiety-like behaviors. Suppression of MARCKSL1 in the amygdala ameliorates both the increase in stress hormones and the elevated anxiety-like behaviors. Our results indicate that MARCKSL1 expression in the amygdala plays an important role in anxiety-like behaviors.

This was proved, in part, by the knockdown of MARCKSL1 in vivo in mice using our i-FectTM. Tanaka, Takashi; Shimizu, Shoko; Ueno, Masaki; Fujihara, Yoshitaka; Ikawa, Masahito; Miyata, Shingo. MARCKSL1 Regulates Spine Formation in the Amygdala and Controls the Hypothalamic-Pituitary-Adrenal Axis and Anxiety-Like Behaviors. https://doi.org/10.1016/j.ebiom.2018.03.018

Figure: Knockdown of MARCKSL1 ameliorates anxiety-like behavior in MARCKSL1 Tg mice. (A and B) For the in vivo experiment, siRNA (blue) was injected into the CeA (total 4 sites) with i-Fect siRNA transfection reagents 5 days prior to behavioral tests. (C) In situ hybridization for Marcksl1 mRNA (blue) in the amygdala after injection of Marcksl1 siRNA into the CeA of Tg/Tg mice. Scale bar, 200 μm. (D and E) Light/dark transition test and elevated plus maze performance in 
MARCKSL1 knockdown mice (WT + control siRNA, n = 7; Tg/Tg + control siRNA, n = 7; Tg/Tg + Marcksl1 siRNA, n = 8).

We will continue to post new i-Fect results here.

Friday, March 23, 2018

Give it a Try

You will be Satisfied
Our FBS is growing in popularity over the past year. In follow up with users, we learned that our low price catalyzed their trying, but its potency resulted in high levels of satisfaction.

Here are some recent reviews:

  • I enjoyed working with the people at Neuromics. The sale person was very friendly and willing to take extra time to solve our problems. Organization: Mayo User: Wenqian Hu - Oct 15, 2017 - Rating: 5.0 
  • Great Service. Got the products in a very prompt manner! Kemin AgriFoods North AmericaVM - Jul 27, 2017 - Rating: 4.0 
  • Fast and easy supplier to work with! Organization: Fresenius KabiChris - Jun 29, 2017 - Rating: 4.0


Our FBS is 9CFR-tested, meeting FDA and USDA requirements. Fetal bovine serum products can also be tested to meet EMEA requirements. We source our FBS cell culture medium supplement from the United States.
Vascular Smooth Muscle Cells cultured in media supplemented with our FBS
We are offering you our FBS for 299 USD/500 ml. Just use the promo code "April". We offer 100% refunds should it not work as expected.

Thursday, March 15, 2018

Great Growth Factors

Potent and Proven

Our growth factors continue to be referenced in leading publications.  They are excellent for amping up your stem-cell expansion and differentiation media-Tom Kamperman, Sieger Henke, Claas Willem Visser, Marcel Karperien, Jeroen Leijten. (2017). Centering Single Cells in Microgels via Delayed Crosslinking Supports Long-Term 3D Culture by Preventing Cell Escape. Small, doi: 10.1002/smll.201603711.
We will continue to post updates.

Thursday, March 01, 2018

HUVECS in 3-D Action

Form Vascular Networks in Microfluidics Model
In this study, the authors developed a 3D functional human microvascular network in a microfluidic device. The established model enables Neuromics GFP-labeled human umbilical vein endothelial cells to form vessel-like microtissues and have physiological functions which are closer to cells in human blood vessels. The perfusable microvasculature allows the delivery of nutrients, and oxygen, as well as flow-induced mechanical stimuli into the luminal space of the endothelium. The microflow effectively mimic the blood flow in human vessels.

This in-vivo like model is then used for toxicity assays-Yan Li, Qing-Meng Pi, Peng-Cheng Wang, Lie-Ju Liu, Zheng-Gang Han,Yang Shao, Ying Zhai, Zheng-Yu Zuo, Zhi-Yong Gong, Xu Yang and Yang Wu. Functional human 3D microvascular networks on a chip to study the procoagulant effects of ambient fine particulate matter. : RSC Adv., 2017, 7, 56108
Images: Microvascular network formation based on microfluidic 3D HUVEC culture. (A) Schematic diagram of a microfluidic device. (B) Schematic diagram of microvascular network formation based on microfluidic 3D HUVEC culture. (C) Schematic diagram of loading microparticles in microvascular networks. (D) Microscope image of HUVECs seeding in fibrin hydrogel. (E) Confocal microscope image of fluorescent microvascular networks.
Our human primary and stem cells are widely used and frequently published. We will continue to post relevant results from researchers using the cells here.

Thursday, February 22, 2018

Primary Human Astrocytes vs Derived Astrocytes Cell Lines

Potent, Pure and Easy to Culture

We are often asked how our human primary astrocytes stack up versus engineered astrocyte cell lines. Astrocyte cultures, whether primary or engineered, need to mimic how they work in-vivo.

This publication is a comprehensive study of the capabilities of our primary astrocytes versus engineered cells. Anders Lundin, Louise Delsing, Maryam Clausen, Piero Ricchiuto, José Sanchez, Alan Sabirsh, Mei Ding, Jane Synnergren, Henrik Zetterberg, Gabriella Brolén, Ryan Hicks, Anna Herland, and Anna Falk. (2018). Human iPS-Derived Astroglia from a Stable Neural Precursor State Show Improved Functionality Compared with Conventional Astrocytic Models. Stem Cell Reports. DOI: https://doi.org/10.1016/j.stemcr.2018.01.021.

With the exception of glutamate uptake, our primary cells talk and walk like astrocytes. We do plan on running assays to test for glutamate uptake as we believe the cells are capable.

It is important that all our human neurons, astrocytes, microglia and schwann cells are potent, pure and easy to culture. As you can see from this graphic, our "primary astros" our positive for most the required characteristics.

Monday, February 19, 2018

i-Fect Delivers Again and Again

Silencing Lactate Dehydrogenase A in vivo

Pathologic CNS is characterized by neuronal damage that leads to the release of intracellular components. However, the effect of damaged cells on angiogenesis has not been clarified. This study revealed that LDHA, which is a known damage marker, promotes CNS-specific angiogenesis. LDHA-mediated angiogenesis depends on vimentin on the surface of vascular endothelial cells. The work described here proposes a novel mechanism by which neurodegeneration drives angiogenesis in the CNS.

A mixture of our i-FectTM and LDHA siRNA, in this study, were directly injected into mice cortexes: Hsiaoyun Lin, Rieko Muramatsu, Noriko Maedera, Hiroto Tsunematsu, Machika Hamaguchi, Yoshihisa Koyama, Mariko Kuroda, Kenji Ono, Makoto Sawada, Toshihide Yamashita. Extracellular Lactate Dehydrogenase A Release From Damaged Neurons Drives Central Nervous System Angiogenesis. doi.org/10.1016/j.ebiom.2017.10.033.
Images: LDHA is sufficient to evoke CNS angiogenesis. (a) Representative images of CD105-labeled spinal cord sections obtained 7 days after LDHA administration. (b) Length of CD105+ neovessels around the LDHA administration site as indicated in a, n = 5 each. (c) Representative image of a Nissl-stained brain section after controlled cortical impact (CCI). (d) Representative image of the CD105-immunolabelled cerebral cortex obtained 7 days after CCI. (e) Length of CD105+ neovessels around CCI lesions as indicated in d; n = 5 each, all error bars represent the s.e.m. **P < 0.01, Student's t-tests. Scale bars, 200 μm.

The findings reveal unexpected neurovascular interactions in the injured adult CNS that may be relevant to our understanding of neuronal damage, which is a hallmark of many CNS disorders

Thursday, February 15, 2018

iPSC Derived Human Neural Progenitors

Potent, Pure and Easy to Culture

We are pleased to announce the addition of Human Neural Progenitors to our Primary and Stem Cell offering.
Human Neural Progenitors at 95% Confluency
Cell potency, for us, includes the how well our cells can be differentiated into terminal types. For these progenitors, we have protocols for differentiating into neurons, astrocytes, and oligodendrocytes.
Neural Progenitors differentiated into Neurons and Stained with Tuj-1
We also have Neural Progenitors from Alcohol and Opioid-Addicted Donors.

Wednesday, February 07, 2018

Culturing Cells in Defined 3-D Structures

Media Supplements Matter

There have been several publications referencing use of our growth factors in 3-D Cultures. It is important that potent growth factors are used to ensure proper cell growth and differentiation.

Here's a new publication referencing use of our ISOKineTM FGF. Our ISOKine growth factors are produced in the endosperm tissue of barley grain (Hordeum vulgare), that exhibits up to 50 times less protease activity than E.coli or mammalian cells. Barley seed is void of any human or animal viral contaminants that could jeopardize your cell culture.

Claas Willem Visser, Tom Kamperman, Lisanne P. Karbaat, Detlef Lohse and Marcel Karperien. In-air microfluidics enables rapid fabrication of emulsions, suspensions, and 3D modular (bio)materials. Science Advances 31 Jan 2018: Vol. 4, no. 1, eaao1175 DOI: 10.1126/sciadv.aao1175. In this study, the authors present in-air microfluidics (IAMF), a new chip-free platform technology that enables in-flight (that is, on-the-fly) formation of droplets, fibers, and particles and their one-step deposition into 3D constructs with a modular internal architecture.
Figure: Concept of IAMF and guide to the article. (A) Chip-based microfluidics enables in-line control over droplets and particles, making it a versatile platform technology. A chip design where droplets (blue) are transported by a coflow (pink) is shown. (B) IAMF maintains the in-line control of chip-based microfluidics but relies on jet ejection and coalescence into air. Therefore, a wide range of droplets and particles can be produced at flow rates typically two orders of magnitude higher than with chip-based microfluidics. When combining reactive, solidifying microjets, IAMF also enables on-the-fly production and direct deposition of microparticles into 3D multiscale modular (bio)materials.

Figure: One-step additive manufacturing and injection molding of 3D multiscale modular (bio)materials. (A) Modular free forms with a controlled microarchitecture were manufactured by stacking of shape-stable core-shell particles. (B to D) A hollow cylinder was formed by deposition of the composite jet onto a rotating substrate. By altering the building blocks’ composition, the resulting microarchitecture consisted of (C) a liquid-filled foam or (D) a multimaterial modular solid, where the cross-linker for the core was added to the shell and vice versa. (E) To eject a modular filler, only the droplets’ cores are solidified in the air, whereas the slower solidifying shells enable seamless filling of the mold. (F to H) A modular construct was produced by filling a bone-shaped mold. Inset: Hydrogel construct while still in the mold. The 3D multiscale modular material consisted of MSCs (pink), encapsulated in alginate microspheres (green) that are embedded in dextran-tyramine hydrogel (red). (I) Injection-molded multiscale modular tissue construct with optimized cellular micro- and macroenvironments. The construct consisted of insulin-producing pancreatic β cells (MIN6; beige with blue nuclei) that were encapsulated in alginate microparticles (green). The cell-laden microparticles were encapsulated within a proangiogenic fibrin network that contained human endothelial and stem cells (pink with blue nuclei). The microenvironments supported MIN6 cell proliferation, whereas the macroenvironment supported the formation of an endothelial cellular network within 7 days of in vitro culture. HUVEC, human umbilical cord endothelial cell. Scale bars, 1 cm (B and F), 5 mm (G), and 100 μm (C, D, H, and I).

We live in a 3-D world and 3-D Cell and Tissue Based Assays are a major focus for us. This includes bioinks for 3-D printing.

Sunday, February 04, 2018

Human Hepatocytes

From Healthy and Diseased Donors
We continue to add human primary and derived cells important to your research.

We now have Human Hepatocytes. They come from healthy and drug-addicted donors.

Like all our cells, these are potent, pure and easy to culture.
iPSC Derived Heptocytes
Human HepatocytesHC4230  Cell Assays1,000,000 Cells$795.00
Human HepatocytesHC4230  Cell Assays500,000 Cells$595.00
Human Hepatocytes - Alcohol AddictedHC4230AA  Cell Assays1,000,000 Cells$895.00
Human Hepatocytes - Alcohol AddictedHC4230AA  Cell Assays500,000 Cells$695.00
Human Hepatocytes - Opioid AddictedHC4230OP  Cell Assays1,000,000$895.00
Human Hepatocytes - Opioid AddictedHC4230OP  Cell Assays500,000$695.00

Here's to exciting discoveries.

Wednesday, January 31, 2018

Studying Apoptosis

By Cancer Researchers

Our Apoptosis Kits have proven rock solid in the hands of cancer researchers.

Here's data from a study of the impact of Vestibular schwannoma (VS) on hearing loss.
Images: Spiral Ganglion Cells labeled with our polycaspase kit stain to identify apoptotic cells.

Tuesday, January 23, 2018

Culturing Neurons on Conductive Biomaterials

Neuromics' Neurons on Graphene
Conductive biomaterials are an ideal bio-substrate for modifying cellular behaviors by conducting either internal or external electrical signals.

In this study, researchers successfully culture our cortical neurons on Nonfunctionalized graphene nanosheets (NGN): Shiyun Meng, Rong Peng. Growth and Follow-Up of Primary Cortical Neuron Cells on Nonfunctionalized Graphene Nanosheet Film. Article first published online: January 18, 2018. https://doi.org/10.5301/jabfm.5000263.
Figure: Spray-coating a nonfunctionalized graphene nanosheet (NGN) on a glass slide. To fix the NGN onto the glass slide, polyurethane (PU) was firstly spin-coated onto glass slides as a polymer matrix, then NGN particles were spray-coated on by airbrush.
Figure: Nuclei formed in 7 and 14 days of cell culture are shown at a relatively high magnification (scale bar = 50 μm): 1/500 MAP-2 (H-300) and 1/500 Alexa Fluor® 488 anti-Rabbit stained green for neuron microtubules and DAPI stained blue neuron nuclei.

We have a large catalog of potent, proven and pure human and animal cells.

Monday, January 15, 2018

Cells from Diseased Donors

Focus on Neuro Diseases

We now have the capability to provide cells of the central and peripheral nervous system from donors with Neuro diseases. These include cells from donors with ALS, AD, PD, and Brain Cancer Donors, to name a few.


We have provided cells to virtually all the large Pharmas and many small and mid-size Bio-techs. We have worked with Novartis to gain 21-CFR compliance for cells that they are using for their eye diseases drug discovery programs.

I am at your “beck and call” should you have interested in exploring specific capabilities further. You can e-mail or call me at 612-801-1007

Tuesday, January 09, 2018

Microvascular Endothelial Cells

Tested, Characterized and Research Ready
Our Microvascular Endothelial Cells continue to work and work in the hands of our customers.

Check out these pubs:
1. Odunayo O. Mugisho, Colin R. Green, Jie Zhang, Nicolette Binz, Monica L. Acosta, Elizabeth Rakoczy and Ilva D. Rupentha. (2017). Immunohistochemical Characterization of Connexin43 Expression in a Mouse Model of Diabetic Retinopathy and in Human Donor Retinas. Int. J. Mol. Sci. doi: 10.3390/ijms18122567
 2. Michael Anthony Ruiz, Biao Feng, and Subrata Chakrabarti. (2015). Polycomb Repressive Complex 2 Regulates MiR-200b in Retinal Endothelial Cells: Potential Relevance in Diabetic Retinopathy. PLoS One.10(4): e0123987. doi: 10.1371/journal.pone.0123987.

In these, our cells are used as "healthy controls" to study Diabetic Retinopathy.

Figure: Connexin43 (green) and GFAP (red) expression in normal and human DR donor retinas in regions of extensive vascular damage. Large cells (white arrows, left column) represent non-specific auto-fluorescent amacrine cells. Connexin43 expression was markedly higher in the GCL of DR donor tissues compared to age-matched controls, and was strongly expressed throughout all retinal layers. GFAP labeling was also markedly higher in DR compared to normal donor eyes representing hyper-reactive Müller cells. Connexin43 expression was increased in regions identified as blood vessels and correlated with increased GFAP labeling at these sites, indicating glial cell activation (white circle). GCL = ganglion cell layer; IPL = inner plexiform layer; INL = inner nuclear layer; OPL = outer plexiform layer; ONL = outer nuclear layer. Scale bar: 200 µm
We stand ready to serve you. Pete Shuster, CEO and Owner, pshuster@neuromics.com

Wednesday, January 03, 2018

Medical Grade Soluble Collagen

New Products-New Applications

We are pleased to announce the addition of  Medical Grade Collagen to our Cell Based Assay Solutions. Applications include:
  • Tissue engineering 
  • Wound healing
  • Medical device coatings
  • 3D cell cultures
  • Drug delivery 
  • Sealants 
  • Electrospinning
  • Hemostats
  • 3D printing
This example outlines how this collagen can be used for cartilage regeneration from mesenschymal stem cells. Acta Biomater. 2016 Jan;30:212-221. doi: 10.1016/j.actbio.2015.11.024. Epub 2015 Nov 18.

Figure: Fabrication of macroporous woven scaffolds and pellet delivery via the macroporous woven collagen scaffold; (a) Liquid to solid phase transition of collagen molecules via electrocompaction to fabricate electrochemically aligned collagen threads and electrocompacted sheets. (b) Collagen thread is woven around a set of pins and threads are stabilized by crosslinking two collagen sheets on top and bottom of woven part of scaffold. (c) Schema of the final woven collagen scaffold. (d) 1 million MSCs pelletized at 500 ×g for 12 minutes, cultured for 3 days and then transferred in to scaffold holes.
SIGNIFICANCE: Mesenchymal condensation is critical for driving chondrogenesis, making high density cell seeding a standard in cartilage tissue engineering. Efforts to date have utilized scaffold free delivery of MSCs in pellet form. This study developed a macroporous scaffold that is fabricated by weaving highly aligned collagen threads. The scaffold can deliver high density cell condensates while providing mechanical stiffness comparable to that of cartilage. The scaffold also mimicked the arcade-like orientation of collagen fibers in cartilage. A highly robust chondrogenesis was observed in this mesenchymal cell pellet delivery system. Baseline mechanical robustness of this scaffold system will enable delivery of cell pellets as early as three days.

Thursday, December 21, 2017

Cell to Cell Signaling and Depression

ATP and Your Brain
A recent article in Molecular Psychiatrydoi:10.1038/mp.2017.229 elucidates the role of ATP and Neuron-Glial interactions in depression.

This study also features the use of our excellent GFAP markers
Abstract: Extracellular ATP is a widespread cell-to-cell signaling molecule in the brain, where it functions as a neuromodulator by activating glia and neurons. Although ATP exerts multiple effects on synaptic plasticity and neuro-glia interactions, as well as in mood disorders, the source and regulation of ATP release remain to be elaborated. Here, we define Calhm2 as an ATP-releasing channel protein based on in vitro and in vivo models. Conventional knockout and conditional astrocyte knockout of Calhm2 both lead to significantly reduced ATP concentrations, loss of hippocampal spine number, neural dysfunction and depression-like behaviors in mice, which can be significantly rescued by ATP replenishment. Our findings identify Calhm2 as a critical ATP-releasing channel that modulates neural activity and as a potential risk factor of depression.

Wednesday, December 13, 2017

Big Thank You!

Big Year
We exceeded our goals for 2017. By a lot. Both in sales and new products.

I would like to personally thank our customers, collaborators, and friends for making this happen. You made it happen.

I wish Joy to you in 2018!
I wish you exciting, new discoveries, and adventures.

Pete Shuster, CEO and Owner, Neuromics.

Friday, December 08, 2017

Coming Soon Hepatocytes and CSCS

Differentiated from iPSCs

Neuromics is partnering with Javeen Biosciences to bring you Cancer Stem Cells and Hepatocytes derived from donor Induced Pluripotent Stem Cells.

Rodney Nash, Javeen CEO, and his team are working to fill a major gap in cell-based drug discoveries. The lack of cells from specific diseased or ethnic populations. This limits the ability to predict how well a drug candidate will work with a diverse population of patients.


Dr. Rodney Nash, CEO, Javeen Biosciences
Over time, we envision Javeen Biosciences as having the ability to engineer cells from donors that match tightly with the needs of drug hunters.

We ask you to "Think of 8". This video illustrates the power Javeen Biosciences' solutions

Much more to follow...

Wednesday, November 29, 2017

Need Cells? Contest is Now Live

It's Easy! 
Creatively insert your favorite human cell culture(s) anywhere into a picture of your lab for $25 Amazon Gift Card. To enter, email the picture to rose@neuromics.com with a description of the image that includes your name, the lab name and the type of cells being cultured.
First 100 entries are eligible for the gift card.

Grand prize is $500 Visa Gift Card. Only entries that include the culture of Neuromics cells will be eligible for the grand prize.

  • Official Contest Rules: 
  • Only one entry per lab. 
  • The first 100 entries are eligible. 
  • Cells cultured do not have to be Neuromics cells to be eligible for Amazon gift card. 
  • All images should be original work – you should not distribute, or reproduce in any way any copyrighted material, trademarks, or other proprietary information without obtaining the prior written consent of the owner of such rights. 
  • By entering this competition, entrants agree that Neuromics can publicize their name, their lab and their entry. 
  • Entries will be posted on Neuromics’ web page, social media channels and other promotional communications. 
  • All submissions become the sole property of Neuromics and will not be returned to the applicant. Prize restrictions may apply to certain individuals based on their institution’s respective policies; based on this, Neuromics reserves the right to decline a prize to ineligible individuals. 
  • Neuromics reserves the right to make any determinations about prizes, disqualifications, and other concerns as issues arise. 
  • Neuromics reserves the right to amend or withdraw the contest at any time.
Enjoy and good luck!

Tuesday, November 21, 2017

Need Cells? Contest

We're live; Be Creative
We are offering a $25 Amazon Gift Card to scientists who creatively places images their favorite cell cultures anywhere in a picture of their lab AND if the picture has images of our human cells, you could win a $500 VISA card.

Here's a link to learn more about our Need Cells Contest.

Please email your picture to rose@neuromics.com and we will email you a $25 Amazon Gift Card.

Thursday, November 16, 2017

Coming Soon-Need Cells? Contest

Creativity Rewarded
We are revving up another contest as our Neuromics Brain Adventure was successful and wow, were people creative.

We are expert at finding human primary and stem cells so cell cultures are central to the contest. Rules are simple. Affix an image of your favorite cell culture anywhere in your lab and we will email you a $25 Amazon gift card.

The contest will run for 3 months and the most creative entry will receive a $500 Visa Gift Card.
Simply e-mail your entry to rose@neuromics.com and we will email back the gift card. Multiple entries encouraged.

Monday, November 06, 2017

More FBS Data!

Cells+Media Supplemented with our FBS!

We continue to be pleased with the cell culture images our customers are sharing with us-https://www.neuromics.com/fbs-data

Neurons are notoriously hard to culture. Here're images of Mouse Neurons cultured in media supplemented with our FBS.
Images: Mouse cortical neurons in culture, using Neuromics heat-inactivated FBS (in plating media for two days). Data courtesy of Dr. Saif at Barrow Neurological Institute.
We continue to offer $50 Amazon Gift Card in return for data you share using any of our solutions. Just email the data to Rose Ludescher, Manager of Customer Satisfaction, rose@neuromics.com and she will email you the gift card.

Monday, October 23, 2017

3-D Retina Organoid Challenge

Proud Sponsor
The National Eye Institute has its sights set on stimulating researchers to move rapidly toward treatments for retinal diseases. We need your scientific expertise: compete in a Challenge to develop a physiologically-competent 3-D retina organoid model.
Check us out on their Sponsor's Page.


Thursday, October 12, 2017

More Neuromics' FBS Related Data

Cells Cultured in Media Supplemented with our FBS
Customers continue submitting data. Here's the latest:
Primary mouse vascular smooth muscle cells stained with smooth muscle alpha-actin in DMEM with Neuromics 10% FBS. Image courtesy of Deng-Fu Guo, University of Iowa.
HEK Cells Grown in Neuromics FBS. Image courtesy of Kavita Shah, Purdue University.
We will continue be posting new FBS related data here.