Neuromics Microglia in Action

 Researchers Study Migration of Neuromics Microglia in Bio-Scaffolds

Check out the publication-https://www.sciencedirect.com/science/article/pii/S2405844023005595.

Images: Migration of Microglia

Here's a link to Neuromics' portfolio of cells for Neurocientists-https://www.neuromics.com/neurons-astrocytes-schwann-cells-microglia.

Markers for Tyrosine Hydroxylase-TH

Proven and Published
Tyrosine hydroxylase TH is a necessary enzyme to create neurotransmitters and protect the body against oxidative stress.

Dysregulation of this enzyme results in manic-depression and schizophrenia. Parkinson's disease is also considered a TH deficiency as low dopamine levels are a consistent neurochemical abnormality.

Markers to TH are important for studying its role in neurotransmission and how it is altered in disorders and diseases.

We have many options and this enables you to choose the best markers for your research. All are proven and published.

TH staining of mouse salivary gland tissue. https://doi.org/10.1016/j.omtm.2018.02.008

Check out all our markers for neuroscience research.

Small Molecules-Peptides for Neuroscience Research

Agonists, Antagonists, Inhibitors and Ligands for Studying Neuromodulation

Our friends at R and D Systems/Tocris Bioscience have made available to us select Small Molecules/Peptides. Our focus will be on providing agonists, antagonists, inhibitors and ligands that complement our Neuroscience and Pain Research products and expertise.

2-APB=TRP Channel Modulator

We will be adding about 10 new molecules/peptides per month. Here's a sampling our our most recent additions:

Name	Type	Bioactivity
(±)-trans-ACPD	Agonist	Potent NMDA agonist. Also group II mGluR agonist
(S)-(-)-5-Fluorowillardiine	Agonist	Very potent AMPA agonist
(S)-4-Carboxyphenylglycine	Antagonist	Competitive group I mGluR antagonist/weak group II agonist
2-APB	Modulator	TRP channel modulator. Also IP3 receptor antagonist
2-Methylthioadenosine triphosphate tetrasodium salt	Agonist	P2 purinergic agonist
AM 404	Modulator	Vanilloid receptor agonist. Also anandamide transport inhibitor
BRL 52537 hydrochloride	Ligand	Potent and selective κ opioid receptor agonist
CNQX	Antagonist	Potent AMPA/kainate antagonist
Clocinnamox mesylate	Antagonist	Irreversible μ-opioid receptor antagonist
Endomorphin-1	Agonist	Potent and selective μ opioid receptor agonist
Endomorphin-2	Agonist	Potent and selective μ opioid receptor agonist
FIT	Agonist	Irreversible δ opioid receptor agonist
GBR 13069 dihydrochloride	Agonist	Potent dopamine uptake inhibitor
L-NIO dihydrochloride	Inhibitor	Potent eNOS inhibitor
L-Quisqualic acid	Agonist	Very potent group I mGluR agonist
N-Benzylnaltrindole hydrochloride	Agonist	Opioid receptor selective non-peptide antagonist
Nociceptin	Inhibitor	Endogenous NOP agonist
O-Phospho-L-serine	Antagonist	Group III mGluR agonist; enhances neuronal differentiation
Ro 51	Antagonist	Potent P2X3, P2X2/3 antagonist
cis-ACPD	Agonist	Potent NMDA agonist. Also group II mGluR agonist

We will be posting new additions and related data and publications

JoVE: Generation of Single-Cell Suspensions from Mouse Neural Tissue (Video Protocol)

JoVE: Generation of Single-Cell Suspensions from Mouse Neural Tissue (Video Protocol)

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APJ (Apelin Receptor) in the Gut

Great Image of our APJ-Catalog#:MO15011

Image: Confocal microscopy of rabbit gastric gland distinguishing the distribution of HDC and the apelin receptor. Green pseudocolor: FITC-coupled polyclonal anti-HDC ab. Red pseudocolor: TRITC-coupled monoclonal anti-APJ receptor ab. Two cells in this gland show specific anti-AJP receptor and anti-HDC staining. Right: a higher magnification scan of the cell in the top right corner of the left panel showing peripheral APJ receptor localization and central perinuclear HDC staining. Physiol. Genomics 25: 153-165, 2006