Introducing our Prostate Cancer Cells Lines

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Neuromics is pleased to introduce many of the top human prostate cancer cell lines to our already expansive selection of cell offerings. To complement the DU 145 cells we added earlier this year, Neuromics is now offering VcaP, LNCaP, and PC-3 cells to complete our catalog of human prostate cancer cell lines.

Image: VcaP cells in culture.

VCaP cells are known for their high androgen receptor and PSA expression. Unlike most other prostate cancer cell lines, LNCaP cells are highly sensitive to androgens and have a low tumorigenicity. Meanwhile, PC-3 cells are noted for their high metastatic potential along with their insensitivity to androgens and fibroblast growth factors. Lastly, DU 145 cells are not hormone-sensitive and do not express PSA.

Cancer-Associated Fibroblasts and Cancer Cell Migration

Highway for Cancer Metastasis

Cancer Associated Fibroblasts provide the Matrices  (ECMs) serve as cancer’s assistants as it spreads throughout the body.

Cancer cells (red) migrate on a CAF-derived extracellular matrix (green). VANDERBILT UNIVERSITY; BEGUM ERDOGAN, DONNA WEBB

Unlike other ECMs, which normally form dense meshes, these arrange into parallel bundles forming the highway for tumor cell migration (The Scientist-December 15, 2015).