Our Markers for Pain Research are widely used and frequently published. They are often referenced in publications on Diabetic nerve pain.
Here are some of my past blog postings:
- Cytokines and Neuropathic Pain
- Epidermal Nerve Fibers in Neuropathic Pain Model
- Pain Research and Gene Expression Analysis
A: Simplified model of nociception under normal conditions. Free nerve endings transduce a painful stimulus into a neural signal, which propagates to DRG centrally and eventually synapses on a nociceptive neuron within the DH of the spinal cord.B: Proposed model of nociception under conditions of diabetic hyperalgesia and allodynia. A pain signal augmented by upregulated pronociceptive ion channels in sensory neurons is carried toward the DH, where it is further augmented by a hypoactive GABAergic system and subsequently diminished inhibition from an inhibitory interneuron. NMDAR, N-Methyl-D-aspartate receptors. https://doi.org/10.2337/dbi15-0006
We will continue to post findings on the root causes and potential treatment for Neuropathy.