Tuesday, November 27, 2018

Pain Receptors and Diabetic Neuropathy

We Got the Markers
Our Markers for Pain Research are widely used and frequently published. They are often referenced in publications on Diabetic nerve pain.

Here are some of my past blog postings:
Here's a model of the actual nerve receptors behind both intractable pain and loss of sensation.
A: Simplified model of nociception under normal conditions. Free nerve endings transduce a painful stimulus into a neural signal, which propagates to DRG centrally and eventually synapses on a nociceptive neuron within the DH of the spinal cord.B: Proposed model of nociception under conditions of diabetic hyperalgesia and allodynia. A pain signal augmented by upregulated pronociceptive ion channels in sensory neurons is carried toward the DH, where it is further augmented by a hypoactive GABAergic system and subsequently diminished inhibition from an inhibitory interneuron. NMDAR, N-Methyl-D-aspartate receptors. https://doi.org/10.2337/dbi15-0006
We will continue to post findings on the root causes and potential treatment for Neuropathy.

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