Small Molecules/Peptides for Pain Researchers

Agonists, Antagonists, Inhibitors and Ligands

The roots of Neuromics is providing solutions for the study of nociceptive and neuropathic pain. Our tools are widely used and frequently published. We are pleased to bring you these small molecules designed to help you better understand the roots of pain and potential therapies.

Figure: Infarct volume after 3 days of reperfusion in the ipsilateral cortex and CP complex in male rats treated with vehicle saline (n=15) or 1 mg/kg per hour BRL 52537 (n=15) started at onset of reperfusion and continued for 22 hours (male-vehicle n=15; male-BRL n=15; mean±SEM). P<.0.05. Related Pub.

Name	Catalog #	Type	Size	Price
(±)-trans-ACPD	187-10	Agonist	10 mg 50 mg	$165 $665
(S)-4-Carboxyphenylglycine	323-10	Antagonist	10 mg 50 mg	$319 $1,319
2-APB	1224-10	Modulator	10 mg 50 mg	$99 $299
2-Methylthioadenosine triphosphate tetrasodium salt	1062-10	Agonist	10 mg	$299
AM 404	1116-10	Modulator	10 mg 50 mg	$119 $449
BAN ORL 24	3661-10	Antagonist	10 mg 50 mg	$183 $795
BRL 52537 hydrochloride	699-10	Ligand	10 mg 1 mg	$159 $609
CTAP	1560-1	Antagonist	1 mg	$135
Clocinnamox mesylate	898-2	Antagonist	2 mg	$179
Endomorphin-1	1055-5	Agonist	5 mg	$139
Endomorphin-2	1056-5	Agonist	5 mg	$139
FIT	1480-10	Agonist	10 mg 10 mg	$229 $929
N-Benzylnaltrindole hydrochloride	0754-10	Agonist	10 mg 10 mg	$199 $809
Nociceptin	910-1	Inhibitor	1 mg	$179
Nocistatin or NST	1198-1	Inhibitor	1 mg	$195

Questions? Do not hesitate to contact me @ pshuster@neuromics.com or 612-801-1007. Thank you! Pete Shuster, CEO and Owner, Neuromics.

Small Molecules-Peptides for Neuroscience Research

Agonists, Antagonists, Inhibitors and Ligands for Studying Neuromodulation

Our friends at R and D Systems/Tocris Bioscience have made available to us select Small Molecules/Peptides. Our focus will be on providing agonists, antagonists, inhibitors and ligands that complement our Neuroscience and Pain Research products and expertise.

2-APB=TRP Channel Modulator

We will be adding about 10 new molecules/peptides per month. Here's a sampling our our most recent additions:

Name	Type	Bioactivity
(±)-trans-ACPD	Agonist	Potent NMDA agonist. Also group II mGluR agonist
(S)-(-)-5-Fluorowillardiine	Agonist	Very potent AMPA agonist
(S)-4-Carboxyphenylglycine	Antagonist	Competitive group I mGluR antagonist/weak group II agonist
2-APB	Modulator	TRP channel modulator. Also IP3 receptor antagonist
2-Methylthioadenosine triphosphate tetrasodium salt	Agonist	P2 purinergic agonist
AM 404	Modulator	Vanilloid receptor agonist. Also anandamide transport inhibitor
BRL 52537 hydrochloride	Ligand	Potent and selective κ opioid receptor agonist
CNQX	Antagonist	Potent AMPA/kainate antagonist
Clocinnamox mesylate	Antagonist	Irreversible μ-opioid receptor antagonist
Endomorphin-1	Agonist	Potent and selective μ opioid receptor agonist
Endomorphin-2	Agonist	Potent and selective μ opioid receptor agonist
FIT	Agonist	Irreversible δ opioid receptor agonist
GBR 13069 dihydrochloride	Agonist	Potent dopamine uptake inhibitor
L-NIO dihydrochloride	Inhibitor	Potent eNOS inhibitor
L-Quisqualic acid	Agonist	Very potent group I mGluR agonist
N-Benzylnaltrindole hydrochloride	Agonist	Opioid receptor selective non-peptide antagonist
Nociceptin	Inhibitor	Endogenous NOP agonist
O-Phospho-L-serine	Antagonist	Group III mGluR agonist; enhances neuronal differentiation
Ro 51	Antagonist	Potent P2X3, P2X2/3 antagonist
cis-ACPD	Agonist	Potent NMDA agonist. Also group II mGluR agonist

We will be posting new additions and related data and publications