Dr. Y.K. Prakash and his team at Mayo Clinic College of Medicine have published a study of Neurotrophin Signaling in Airway Smooth Muscle (ASM) cells. Here they demonstrate that BDNF/TrkB signaling (but not BDNF/p75NTR) in human ASM cells regulates [Ca2+]i responses to agonist in both normal ASM, as well as with inflammation induced by TNFα. These effects suggest an important role of NT signaling in inflammation-induced changes in ASM contractility.
Y.S. Prakash, Michael A Thompson, and Christina M Pabelick. Brain Derived Neurotrophic Factor in TNF Modulation of Ca2+ in Human Airway Smooth Muscle. Am. J. Respir. Cell Mol. Biol., Feb 2009; doi:10.1165/rcmb.2008-0151OC.
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