Thursday, February 19, 2009

Neurotrophin Expression in Airway Smooth Muscle Cells

Dr. Y.K. Prakash and his team at Mayo Clinic College of Medicine have published a study of Neurotrophin Signaling in Airway Smooth Muscle (ASM) cells. Here they demonstrate that BDNF/TrkB signaling (but not BDNF/p75NTR) in human ASM cells regulates [Ca2+]i responses to agonist in both normal ASM, as well as with inflammation induced by TNF╬▒. These effects suggest an important role of NT signaling in inflammation-induced changes in ASM contractility.

Y.S. Prakash, Michael A Thompson, and Christina M Pabelick. Brain Derived Neurotrophic Factor in TNF Modulation of Ca2+ in Human Airway Smooth Muscle. Am. J. Respir. Cell Mol. Biol., Feb 2009; doi:10.1165/rcmb.2008-0151OC.
... goat polyclonal anti-TrkB-Cat#: GT15080 (Neuromics, Minneapolis, MN; 1:1000 dilution)...

Featured Reagents
TrkB-Cat#: GT15080
TrkB-Cat#: MO15042
Related Reagents:
TrkB-Cat#: MO15025
TrkA for FC
TrkA Cat#: MO15034
TrkA Cat#: GT15153
All Neurotrophins and Growth Factor Antibodies
All Neurotrophins-Neuron/Glial Marker Antibodies

No comments: