Thursday, April 13, 2017

mGluRs Protect OPCs

Valuable for Remyelination of Damaged Neurons

We add a new publication to our mGluR Markers Category: Arthur M. Butt, Ilaria Vanzulli, Maria Papanikolaou, Irene Chacon De La Rocha, Virginia E. Hawkins. Metabotropic Glutamate Receptors Protect Oligodendrocytes from Acute Ischemia in the Mouse Optic Nerve. Neurochem Res (2017). doi:10.1007/s11064-017-2220-1. Its focus is the protective characteristics of mGluRs.

Images: Expression of mGluR in optic nerve oligodendrocytes. a RT-qPCR of mGluR subtypes in the postnatal (P8–12) and young adult (P30–35) optic nerve, compared to cortex at the same ages (inset); data are expressed as mean ± SEM ΔΔCT relative to GAPDH, ***p < 0.001 determined by ANOVA and post hoc Bonferroni’s test. b, c Oligodendrocytes in optic nerve explant cultures from P8 PLP-DsRed reporter mice after 10 DIV were immunolabelled for mGluR2/3 (d) and mGluR5 (e), illustrating single channels (Di, Dii, Ei, Eii) and the merged channel in which mGluR colocalization with PLP appears white (Diii, Eiii); scale bars 10 µm

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