ERK1/2 Signaling and Depression
Extracellular signal-regulated kinase 1/2- (ERK1/2-) mediated cellular signaling plays a major role in synaptic and structural plasticity. Although ERK1/2 signaling has been shown to be involved in stress and depression. Phosphorylation of the receptor is important for maintaining healthy signaling, reduction of oxidative stress and induction of growth factors.
We are pleased that our ERK1/2 markers have been published in these type of studies. Here's a recent one: MARIA CONCETTA OLIANAS, Simona Dedoni, and PIER LUIGI ONALI. LPA1 mediates antidepressant-induced ERK1/2 signalling and protection from oxidative stress in glial cells. Published online before print September 7, 2016, doi: 10.1124/jpet.116.236455.
...Membranes were incubated overnight at 4 °C with one of the following primary antibodies: anti-phospho-ERK1 (Thr202/Tyr204) / ERK2(Thr185/Tyr187) (RA 15002) (1:15,000) (Neuromics, Northfield, MN, USA.
We will continue to post updates on this important topic
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