Neuropeptides and Large Dense Core Vesicles

We continue to be recognized by for the quantity and quality of our Neuropeptide and Neuropeptide Receptor Antibodies for studying Neurotransmission and Pain.

We wanted to feature an new article referencing use of our Guinea Pig Substance Antibody. Dr. Richard Mains and his team shed light on the function and behavior of large dense core
vesicles (LDCVs) concluding that under basal conditions, LDCVs move faster away from the soma than toward the soma, but fewer LDCVs travel anterograde than retrograde. Stimulation decreased average anterograde velocity and increases granule pausing. Data from antibody uptake, quantification of enzyme secretion and appearance of pHluorin fluorescence demonstrate distributed release of peptides all along the axon, not just at terminals.
Jacqueline A Sobota , William A Mohler , Ann E Cowan , Betty A Eipper and Richard E Mains. Dynamics of peptidergic secretory granule transport are regulated by neuronal stimulation. BMC Neuroscience 2010, 11:32doi:10.1186/1471-2202-11-32.

Image: Sustance P staining of trigeminal ganglia from P3-P5 rat pups-note this pub features some of the best IHC staining we have seen.

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Substance P-Pure
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proNeurokinin B (proNKB or P2)
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Neuropeptide and Neuropeptide Receptor Antibodies
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Primary Neurons and Astrocytes- Primary human, rat and mouse neurons and astrocytes.