Tuesday, February 09, 2010

Turning Placenta Into Brain

We are pleased to feature a recent publication featuring:

C. Bettina Portmann-Lanz PhD, Andreina Schoeberlein PhD, Reto Portmann PhD, Stefan Mohr MD, Pierre Rollini PhD, Ruth Sager1 and Daniel V. Surbek MD. Turning placenta into brain: placental mesenchymal stem cells differentiate into neurons and oligodendrocytes. doi:10.1016/j.ajog.2009.10.893... β-Tubulin III (Tuj-1), Mouse, Neuromics...

The researchers successfully induced neural stem (NSC) and progenitor cells (NPC) from human placental tissues.

Here are the highlights:

Study Design
Placental stem cells from first-trimester placental chorionic villi and term chorion were isolated. Neural differentiation was initiated with plating on collagen, retinoic acid, and/or human brain-derived neurotrophic factor and epidermal and fibroblast growth factor. Differentiation into neurons, oligodendrocytes, and astrocytes was monitored by immunohistochemistry. Two-dimensional polyacrylamide gel electrophoresis, high-performance liquid chromatography, and tandem mass spectrometry were used to identify proteins involved in the differentiation.

Differentiated cells were mostly immediately postmitotic with some more but not fully mature postmitotic neurons. Neurons had dopaminergic or serotonergic character. Some cells differentiated into predominantly immature oligodendrocytes. Upon differentiation, neuron-specific proteins were up-regulated, whereas placental proteins were reduced.

Stem cells derived from human placenta can be differentiated into neural progenitors.

Featured Antibody
Tuj 1 (Neuron-specific class III beta-tubulin)-Mouse

Related Reagents:
NSE (Neuron-Specific Enolase)



Neuron/Glial Markers

Stem Cell Research Reagents

1 comment:

Chloe said...

Generally, placental mesenchymal stem cells differentiate into
neurons so that the details the blog indicated could be reasonable.
Stem cell factor is worthy of further attention.