Our Pain and Inflammation Research Antibodies have proven valuable for the study of neuropathic, nociceptive and inflammatory pain.
This recent publication is focused on Diabetic Neuropathy. José Eduardo Roa-Coria, Jorge Baruch Pineda-Farias, Paulino Barragán-Iglesias, Geovanna Nallely Quiñonez-Bastidas, Ángel Zúñiga-Romero, Juan Carlos Huerta-Cruz, Juan Gerardo Reyes-García, Francisco Javier Flores-Murrieta, Vinicio Granados-SotoView ORCID ID profile and Héctor Isaac Rocha-González (2019). Possible involvement of peripheral TRP channels in the hydrogen sulfide-induced hyperalgesia in diabetic rats. BMC Neuroscience 201920:1 https://doi.org/10.1186/s12868-018-0483-3.
The results show Hydrogen Sulfide (H2S) catalyzes hyperalgesia in rats via TRP Channels. Our Substance P is used in the study.
Figure: Immunolocalization of cystathionin-β-synthase enzyme (CBS, red) with a–e neuronal nuclear antigen (NeuN)-, f–j substance P (SP)-, k–o isolectin B4 (IB4)- and p–t glial fibrillary acidic protein (GFAP)-positive dorsal root ganglion neurons of diabetic rats (green). a, f, k and p show a representative 16 µm-slice from dorsal root ganglia. b, g, l and q show a representative CBS staining with Cy3 from dorsal root neurons, whereas c, h, m and r show NeuN, SP, IB4 and GFAP representative staining with Cy2 in dorsal root neurons, respectively. d, i, n and s show the merged image from Cy3 and Cy2 signals, the overlapping between CBS and neuronal markers is shown in a yellow-orange color. e, j, o and t show a magnification of d, i, n and s, respectively.