Tuesday, January 09, 2018

Microvascular Endothelial Cells

Tested, Characterized and Research Ready
Our Microvascular Endothelial Cells continue to work and work in the hands of our customers.

Check out these pubs:
1. Odunayo O. Mugisho, Colin R. Green, Jie Zhang, Nicolette Binz, Monica L. Acosta, Elizabeth Rakoczy and Ilva D. Rupentha. (2017). Immunohistochemical Characterization of Connexin43 Expression in a Mouse Model of Diabetic Retinopathy and in Human Donor Retinas. Int. J. Mol. Sci. doi: 10.3390/ijms18122567
 2. Michael Anthony Ruiz, Biao Feng, and Subrata Chakrabarti. (2015). Polycomb Repressive Complex 2 Regulates MiR-200b in Retinal Endothelial Cells: Potential Relevance in Diabetic Retinopathy. PLoS One.10(4): e0123987. doi: 10.1371/journal.pone.0123987.

In these, our cells are used as "healthy controls" to study Diabetic Retinopathy.

Figure: Connexin43 (green) and GFAP (red) expression in normal and human DR donor retinas in regions of extensive vascular damage. Large cells (white arrows, left column) represent non-specific auto-fluorescent amacrine cells. Connexin43 expression was markedly higher in the GCL of DR donor tissues compared to age-matched controls, and was strongly expressed throughout all retinal layers. GFAP labeling was also markedly higher in DR compared to normal donor eyes representing hyper-reactive Müller cells. Connexin43 expression was increased in regions identified as blood vessels and correlated with increased GFAP labeling at these sites, indicating glial cell activation (white circle). GCL = ganglion cell layer; IPL = inner plexiform layer; INL = inner nuclear layer; OPL = outer plexiform layer; ONL = outer nuclear layer. Scale bar: 200 µm
We stand ready to serve you. Pete Shuster, CEO and Owner, pshuster@neuromics.com

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