Saturday, September 16, 2017

Dynamics of Stem Cell Differentiation

Differentiation Markers
Neuromics has excellent markers for determining stem cell differentiation.

This new publication references use of our OTX2 marker: Sumin Jang, Sandeep Choubey, Leon Furchtgott, Ling-Nan Zou, Adele Doyle, Vilas Menon, Ethan B Loew, Anne-Rachel Krostag, Refugio A Martinez, Linda Madisen, Boaz P Levi, Sharad Ramanathan. Dynamics of embryonic stem cell differentiation inferred from single-cell transcriptomics show a series of transitions through discrete cell states. eLife 2017;6:e20487. DOI: http://dx.doi.org/10.7554/eLife.20487


Figures: Single-Cell Gene Expression Profiling of mESCs during early germ layer differentiation. (A) Mouse embryonic stem cells (mESCs) were exposed to various differentiation conditions to perturb FGF, WNT, and TGF-beta signaling for up to five days of differentiation. (B) Images of immunostained mESCs undergoing differentiation show cell-to-cell variability in their expression of known germ layer marker genes. (Scale bar = 100 μm).
We will continue to post new developments.

1 comment:

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