A Source for SN-Related Neural Circuits and for Designing Therapeutic Models for Related Diseases.
Researchers have successfully differentiated our hNP1TM Neural Progenitors into Sensory Neurons. These cells can be passaged 10X+ prior to differentiation. This means basic and drug discovery researchers now have a source to generate large quantities of SNs: Xiufang Guo, Severo Spradling, Maria Stancescu, Stephen Lambert, James J. Hickman. Derivation of sensory neurons and neural crest stem cells from human neural progenitor hNP1. Biomaterials, In Press, Corrected Proof, Mar 2013.doi:10.1016/j.biomaterials.2013.02.061.
Images: Generation of Schwann cells from the differentiated culture. Immunostaining of a day 38 culture with the Schwann cell marker S100 demonstrating a significant number of Schwann cells in the culture. Schwann cells were located either within the neuronal clusters (A) or along the axonal bundles (B). The neuronal clusters and axonal bundles were marked by Peripherin immunostaining. doi.org/10.1016/j.biomaterials.2013.02.061
We are developing human cell based assays for High Content and Throughput Screening and will continue to post updates.
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