In this study the authors demonstrate a between SSCs and RET.
ETV5 is expressed beginning in fetal Sertoli cells and can potentially have effects on both neonatal Sertoli and germ cells. In addition, ETV5 has critical effects on neonatal spermatogonial proliferation, which may involve impaired signaling through the RET receptor.
Gaurav Tyagi, Kay Carnes, Carla Morrow, Natalia V. Kostereva, Gail C. Ekman, Daryl D. Meling,
Chris Hostetler, Michael Griswold, Kenneth M. Murphy, Rex A. Hess, Marie-Claude Hofmann and Paul S. Cooke. Loss of Etv5 Decreases Proliferation and RET Levels in neonatal Mouse Testicular Germ Cells and Causes an Abnormal First Wave of Spermatogenesis. DOI:10.1095/biolreprod.108.075200
Images: Ret IHC in WT and Etv5-/- testes (n=4). The intensity of RET staining per spermatogonia is markedly reduced in Etv5-/- testis (B) even though the number of cells staining for RET are comparable to the WT (A) testis. Insets are higher magnification of spermatogonia showing differences in staining intensity. Bars = 50 μm in A and B, insets = 10 μm.Patent:Neuronal progenitors from feeder-free human embryonic stem cell culture.
Inventor: Stice, et al.
Date Issued: May 12, 2009
Application: 11/243,819
Inventors:
Stice; Steve (Athens, GA)Shin; Soojung (Baltimore, MD)Dhara; Sujoy (Athens, GA)
Assignee:
University of Georgia Research Foundation, Inc. (Athens, GA)Include use of Nestin antibody
Stem Cell Antibodies
Stem Cell Research Proteins
Neural Stem Cells and Media
Neuroprogenitor Neurosphere Tissue-NEW!
Neuroprogenitor Neurosphere tissue is provided live, unseparated, fresh from E18 rat cortex/hippocampus including subventricular zone.
Expansion/Differentiation Kits
FACS/Phenotyping
Related Reagents:
Neurotrophin and Growth Factor Antibodies
Neurotrophin Proteins
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