Got Autofluorescence?

Problem Solved!

Autofluorescence muddies data and can lead to incorrect solutions. Using our FluoMate^TM  ,you can trust your results. Check it out today.

FluoMute™ ready-to-use reagent to reduce autofluorescence in cells and tissue. Just incubate fixed cells of tissue sections with FluoMute™ for 30-60 min at room temperature, rinse with PBS and continue with immunofluorescence ICC or/and IHC protocols. Treatment with FluoMute™ does not affect cell morphology and the integrity of tissue antigens to be detected with primary antibodies. FluoMute™ is compatible with paraffin-embedded and frozen tissue sections, stem cells, lymphocytes and mammalian cell lines of different origin.

Hypoxia Induced Angiogenesis and Tumor Microenvironment

Neuromic's HUVECS Used in Study

The tumor microenvironment is essential for promoting tumor physiology, structure, function, and growth. It is important that emerging therapies eradicate both tumors and related microenvironment. This important study focuses on the formation of these microenvironments: ERICA K. SCHNETTLER. THE FUNCTIONAL ROLE OF MIR-210 IN HYPOXIA-INDUCED ANGIOGENESIS. A DISSERTATION SUBMITTED TO THE FACULTY OF THE UNIVERSITY OF MINNESOTA. FEBRUARY 2017...Primary Human umbilical vein endothelial cells (HUVEC) were purchased from Lonza (Basel, Switzerland) and Neuromics (Edina, MN)...

Figure: miR-210 sensitizes HUVECs to bFGF induced tube formation. (A)Representative images of HUVEC tube formation are shown at 10X magnification. Cells were treated with miR-210 or sc-miR, serum starved, and then plated on a Geltrex (reduced growth factor) layer in the presence or absence or bFGF to stimulate tube formation. (B) Histogram represents quantification of total tube length, number of nodes, and junctions in the tube formation assay described in A. Analysis done with ImageJ Angiogenesis Analyzer plugin.

We will continue to post our updates our primary Human Endothelial Cells as they develop.

mGluRs Protect OPCs

Valuable for Remyelination of Damaged Neurons

We add a new publication to our mGluR Markers Category: Arthur M. Butt, Ilaria Vanzulli, Maria Papanikolaou, Irene Chacon De La Rocha, Virginia E. Hawkins. Metabotropic Glutamate Receptors Protect Oligodendrocytes from Acute Ischemia in the Mouse Optic Nerve. Neurochem Res (2017). doi:10.1007/s11064-017-2220-1. Its focus is the protective characteristics of mGluRs.

Images: Expression of mGluR in optic nerve oligodendrocytes. a RT-qPCR of mGluR subtypes in the postnatal (P8–12) and young adult (P30–35) optic nerve, compared to cortex at the same ages (inset); data are expressed as mean ± SEM ΔΔCT relative to GAPDH, ***p < 0.001 determined by ANOVA and post hoc Bonferroni’s test. b, c Oligodendrocytes in optic nerve explant cultures from P8 PLP-DsRed reporter mice after 10 DIV were immunolabelled for mGluR2/3 (d) and mGluR5 (e), illustrating single channels (Di, Dii, Ei, Eii) and the merged channel in which mGluR colocalization with PLP appears white (Diii, Eiii); scale bars 10 µm

Need the Beat?

Check out our Cardiomyocytes!
We are pleased to announce the addition of rat and mouse myocytes to our extensive catalog of primary and stem cells.

Questions? Do not hesitate to contact me directly at pshuster@neuromics.com or 612-801-1007. Thank you. Pete Shuster, CEO and Owner