Sunday, January 29, 2023

Neuromics' Astrocytes/Pericytes used to Form Organoid BBB Model

BBB Model Used to Study How Lyme neuroborreliosis (LNB) penetrates the Brian.

Yvonne Adams, Anne Skovsbo Clausen, Peter Østrup Jensen, Malin Lager, Peter Wilhelmsson, Anna J. Henningson, Per-Eric Lindgren, Daniel Faurholt-Jepsen, Helene Mens, Peter Kraiczy, Kasper Nørskov Kragh, Thomas Bjarnsholt, Andreas Kjaer, Anne-Mette Lebech, Anja R. Jensen, 3D blood-brain barrier-organoids as a model for Lyme neuroborreliosis highlighting genospecies dependent organotropism, iScience, Volume 26, Issue 1, 2023, 105838, ISSN 2589-0042, https://doi.org/10.1016/j.isci.2022.105838.

Image: LNB Penetrating the BBB (green Fluorescence)


Researchers discovered Borrelia spp. exposure triggers a loss of tight junctions. Organoid structural integrity is significantly reduced after Borrelia spp. exposure