Parkinson's Disease and the Striatum

Excellent Video
Researchers at the Karolinska Institute recently released a video outlining their findings regarding the root causes of Parkinson's.

Highlights

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Striatal sensory responses were studied by whole-cell recordings and optogenetics

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Dopamine (DA) depletion affects intrinsic and sensory properties in direct pathway neurons

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The encoding of bilateral tactile stimuli is impaired following DA depletion

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Administration of L-DOPA can correct sensory deficits caused by DA depletion.

for more see: https://doi.org/10.1016/j.neuron.2017.05.004

This study came to my attention the researchers used our Enkaphalin Antibody as a marker for the Dopaminergic Neurons. 

Image: Mouse striatum stained with D2 cell marker Enkephalin (RA14124) in green and with neuronal marker NeuN in red courtesy of Dr Heike Rebholz of City College of New York

Neuropeptides and Stress

Neuropeptides Antagonists, Stress and Alcohol Seeking

Select Neuropeptides can help moderate stress and related Alcohol seeking behaviors. The authors of this study reference use of our ppENK and proDYN Neuropeptides: J.R. Schank,B.S. Nelson,R. Damadzic,J.D. Tapocik,M. Yao,C.E. King,K.E. Rowe,K. Cheng,K.C. Rice,M. Heili. Neurokinin-1 receptor antagonism attenuates neuronal activity triggered by stress-induced reinstatement of alcohol seeking. doi:10.1016/j.neuropharm.2015.07.009.

Image: Mouse striatum stained with D2 cell marker Enkephalin (RA14124) in green and with neuronal marker NeuN in red courtesy of Dr Heike Rebholz of City College of New York.

Our Pain/Inflammation Antibodies are widely used and frequently referenced in studies of stress and the intersection between stress and pain.