BBB Model Used to Study How Lyme neuroborreliosis (LNB) penetrates the Brian.
Yvonne Adams, Anne Skovsbo Clausen, Peter Østrup Jensen, Malin Lager, Peter Wilhelmsson, Anna J. Henningson, Per-Eric Lindgren, Daniel Faurholt-Jepsen, Helene Mens, Peter Kraiczy, Kasper Nørskov Kragh, Thomas Bjarnsholt, Andreas Kjaer, Anne-Mette Lebech, Anja R. Jensen,
3D blood-brain barrier-organoids as a model for Lyme neuroborreliosis highlighting genospecies dependent organotropism,
iScience,
Volume 26, Issue 1,
2023,
105838,
ISSN 2589-0042,
https://doi.org/10.1016/j.isci.2022.105838.
Image: LNB Penetrating the BBB (green Fluorescence)
Researchers discovered Borrelia spp. exposure triggers a loss of tight junctions. Organoid structural integrity is significantly reduced after Borrelia spp. exposure
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