Neuromics' Microvascular Endothelial Cells in Action

 Widely Used and Data Rich

Neuromics Human Brain Microvascular Endothelial Cells (HBMECS) are frequently used and data rich. Here are HBMECS in culture showing early microtubular formation.

HBMECS in culture showing early microtubular formation

They are an excellent component for building Blood-Brain Barrier (BBB) Models. Questions? E-mail Mr. David Rupp-david@neuromics.com. 

Cancer Associated Fibroblasts and Cell Lines

 Wide Variety

Neuromics has a growing catalog of CAFS and Cell Lines. Here's an example of our Breast CAFS.

Breast CAFs in culture. Grown using Stem Cell Complete Low Serum Media (cat. CAFM02)

Cells are prepared and manufactured in an ISO 9001:2015 certified environment and ISO 5 cleanroom.

Questions? email david@neuromics.com

Neuromics' Human Neurons in Action

Our primary human neurons (cat. HNC001) have been busy lately, continuing to become one of our most popular and versatile products. Earlier this month, Japanese researchers published their findings when creating 3D brain-like spheroids containing our primary human neurons. Their results suggest the spheroids mimic in vivo conditions and are suitable for use as an in vitro neurological disease model. Check out the publication for yourself here.

Human Neurons in Culture

Since the beginning of 2022, our neurons have been cited a number of times spanning various research areas. They were used by researchers to suggest a link between the COVID-19 virus and Alzheimer's disease (lean more here). Additionally, investigators published findings (see here) using the neurons to find a potential therapeutics target for neuroblastoma.

Questions? Do not hesitate to contact me pshuster@neuromics.com or 612-801-1007. Pete Shuster-CEO and Owner

Potent and Pure Fetal Bovine Serum

Potent and pure FBS. Single use, triple filtered and manufactured under the strictest guidelines, Pricing starts at $245/500 ml

Check us out Fetal Bovine Serum.

Introducing our Prostate Cancer Cells Lines

 Check out the Options

Neuromics is pleased to introduce many of the top human prostate cancer cell lines to our already expansive selection of cell offerings. To complement the DU 145 cells we added earlier this year, Neuromics is now offering VcaP, LNCaP, and PC-3 cells to complete our catalog of human prostate cancer cell lines.

Image: VcaP cells in culture.

VCaP cells are known for their high androgen receptor and PSA expression. Unlike most other prostate cancer cell lines, LNCaP cells are highly sensitive to androgens and have a low tumorigenicity. Meanwhile, PC-3 cells are noted for their high metastatic potential along with their insensitivity to androgens and fibroblast growth factors. Lastly, DU 145 cells are not hormone-sensitive and do not express PSA.

Neuromics' Human Brian Microvascular Endothelial Cells in Action

Fc-saxatilin inhibits VEGF-induced permeability by regulating claudin-5 expression in human brain microvascular endothelial cells (HBMVECs)

Neuromics' cells were at the heart of this study.

Highlights: 

Fc-saxatilin prevents VEGF-induced permeability in human brain microvascular cells (HBMVECs). 

Fc-saxatilin inhibits VEGF-induced Src and Fak phosphorylation in HBMVECs. 

Fc-saxatilin blocks the downregulation of claudin-5 expression by VEGF in HBMVECs.

Image: HMBECS in Culture

Protocol: Human brain microvascular endothelial cells (HBMVECs) were purchased from Neuromics (HEC02; Minneapolis, MN, USA). HBMVECs were maintained in ENDO-growth medium (MED001; Neuromics). 

Here's a link to the full study: https://www.sciencedirect.com/science/article/pii/S0026286219301177#!

TRPV1 and Migraines

New Links to Insulin

Hungarian researchers used our guinea pig polyclonal TRPV1 receptor antibody (GP14100) to help answer why heightened insulin levels can lead to migraines.

Immunohistochemistry in rat trigeminal ganglion. (A) Trigeminal ganglion neurons in the ophthalmic division immunoreactive for insulin receptor (InsR), TRPV1 receptor and CGRP. (B) Coexpression of insulin receptor (InsR) with TRPV1 receptor and/or CGRP in trigeminal ganglion neurons. Colours representing insulin receptor-, TRPV1 receptor- and CGRP-immunoreactivities and their coexpressions indicated in B applies also to A. (C) A trigeminal ganglion neuron retrogradely labeled with True blue expresses both insulin receptor (InsR) and TRPV1 receptor

Conclusion-the present findings indicate that insulin may activate TRPV1 receptors in the trigeminovascular system. Modified TRPV1 receptor function induced by insulin may also increase the sensitivity of both neural and vascular TRPV1 receptor for its agonists. Our data may provide a pathophysiological basis for the increased incidence of migraine in patients with hyperinsulin levels.