Renal Nerves and Blood Pressure

Role of Calcitonin gene-related peptide (CGRP)

CGRP is a potent vasodilator so it is not surprising our CGRP Antibody was used in this study. Custódio AH, de Lima MC, Vaccari B, Boer PA, Gontijo JAR (2017) Renal sodium handling and blood pressure changes in gestational protein-restricted offspring: Role of renal nerves and ganglia neurokinin expression. PLoS ONE 12(6): e0179499. https://doi.org/10.1371/journal.pone.0179499

Figure. Comparative expression of SP and CGRP in the renal pelvis of 16-week-old rats. The pictures show a normal distribution of these neurokinins in NP (A and D). In LP offspring, no difference was observed in SP immunoreactivity (A, B, and C), but CGRP immunoreactivity was significantly more intense in NP (D, E, and F) compared with age-matched LP offspring.

We are always honored when our solutions are referenced in publications and will continue to post new findings here.