Connective-Tissue Growth Factor (CTGF/CCN2) Induces Astrogenesis

SOX-2 Proves a Marker For Astrogenesis

This proved  surprising to the authors of a recent publication referencing use of our Monoclonal SOX-2 Antibody. We have added our SOX-2 abs to our Glial-Astrocyte Markers. See: Fabio A. Mendes , Juliana M. Coelho Aguiar , Suzana A. Kahn, Alice H. Reis, Luiz Gustavo Dubois, Luciana Ferreira Romão, Lais S. S. Ferreira, Hervé Chneiweiss, Vivaldo Moura Neto, José G. Abreu. Connective-Tissue Growth Factor (CTGF/CCN2) Induces Astrogenesis and Fibronectin Expression of Embryonic Neural Cells In Vitro. Published: August 4, 2015DOI: 10.1371/journal.pone.0133689...monoclonal anti-Sox2 (Neuromics, Acris, Germany) in blocking solution were incubated with the membranes overnight at 4°C, followed by incubation with Peroxidase-conjugated anti-rabbit IgG and peroxidase-conjugated anti-mouse IgG secondary antibodies...

Figure: Exogenous CTGF protein increases the number of Sox2-positive cells of a neural progenitor culture. Immunostaining showing Sox2 (A and D) expression of untreated and CTGF-treated cells. C and F show merged pictures of Sox2 immunostaining together with nuclei-DAPI staining. Scale bars 10 μm. G shows the percentage of cells that were positive for Sox2. doi:10.1371/journal.pone.0133689.g002

Neuromics have a significant catalog of potent and proven Asytoglial, Neuronal, Schwann Cell and Oligodendrocyte Markers.