Neuromics' Renal Proximal Tubule Cells in Action

Human Renal Proximal Tubule Cells Express Klotho

Our human primary cells are widely used and frequently referenced in a variety of publications. In this study, our RPT Cells were used to study the impact of Klothko expression on protection of kidneys in diabetics: Meng Xue, Feng Yang, Ying Le, Yanlin Yang, Bingsen Wang, Yijie Jia, Zongji Zheng, and Yaoming Xue. (2021). Klotho Protects Against Diabetic Kidney Disease via AMPK- and ERK-Mediated Autophagy. Acta Diabetologica, 32. doi: 10.1007/s00592-021-01736-4.

Klotho expression in human renal proximal tubule cells after high-glucose stimulation. (a) Levels of Klotho mRNA and (b) Klotho protein were assessed in human renal proximal tubule cells treated with low glucose and high glu- cose. (c) Morphological observations of Klotho expression by confocal microscopy

Klotho improved renal tubular cell autophagy via the AMPK and ERK path- ways and played a role in renal protection. These findings provide new insight into the mechanism of Klotho and autophagy in DKD.