New 3-D Eye Model

More in-vivo like Model
We see our world in 3-D. Diseases of the eye compromise this ability.

Neuromics' is pleased to announce that we have a 3-D model aimed at accelerating drug discovery for these diseases. Sight is a terrible thing to lose and the faster new drugs can be discovered, fewer people will have to suffer the loss of sight.

Our 3D Human Retinal Microvascular Angiogenesis model is constructed using GFP‐Tagged human Retinal Microvascular Endothelial cells. They are co-cultured with RFP-Tagged human supporting cells. GFP positive human retinal capillary-like tubule formation can be monitored in real time under fluorescence microscope throughout the whole process of the experiment.

Antibodies Against Neuropeptides

Another Nod From Nature Scientific Reports
Publications referencing use of our antibodies continue to build. We are recognized for having potent Neuropeptide Antibodies.

This most recent publication references our Guinea Pig Substance-P Antibody: Khaled Abdallah, Francis Nadeau, Francis Bergeron, Sylvie Blouin, Véronique Blais, Kelly M. Bradbury, Christine L. Lavoie, Jean-Luc Parent;, Louis Gendron. (2018). Adeno-associated virus 2/9 delivery of Cre recombinase in mouse primary afferents. Scientific Reports volume 8, Article number: 7321 (2018) doi:10.1038/s41598-018-25626-y

Figure: Distribution of the Cre-GFP in the neuronal subpopulations within the lumbar dorsal root ganglia. Representative photomicrographs showing co-localization of GFP with markers of peptidergic (Substance P), non-peptidergic (Isolectine B4) and large diameter myelinated (NF200) neurons are shown for mice (n = 6) injected in the plantar surface of both hindpaws with the AAV2/9-CBA-Cre-GFP virus. Arrows indicate neurons co-labeled for GFP and the indicated marker. Scale bars = 50 µm.

We stand behind all our products. If you are not 100% satisfied with one of our antibodies, we offer full replacements or your money back,

Researchers Love our FBS

Potent Serum at a Great Price!
We are pleased by the 5-star ratings on our Fetal Bovine Serum (FBS). Check them out.

• Outstanding service. Fetal bovine serum was of highest quality, easy to order and packaging and shipping were best possible.Rosemary Dziak - May 08, 2018 - Rating: 5.0
• This is first time to buy FBS from them. Rose is very nice person. they make you easy and comfortable to purchase.jie wei - Feb 16, 2018 - Rating: 5.0
• I enjoyed working with the people at Neuromics. The sale person was very friend and willing to take extra time to solve our problems. Product Name: FBS - (Cat#FBS001) https://www.neuromics.com/FBS001 Organization: MayoWenqian Hu - Oct 15, 2017 - Rating: 5.0

All Testimonials
FBS-500 ml-only 349 USD

Our FBS is 9CFR-tested, meeting FDA and USDA requirements. Fetal bovine serum products can also be tested to meet EMEA requirements. Note: We test each lot of FBS on our primary human cell cultures enabling us to choose lots yielding the best results...
Testimonial: "We have used the FBS from Neuromics in feeding media for primary mouse astrocytes as well as for some cell lines. Your product is good and we plan to continue using it.” - Svetlana Vidensky, MS, Senior Research Specialist in Dr. Jeffrey Rothstein lab, Department of Neurology, Johns Hopkins University Contact Rose at rose@neuromics.com or 952-374-6161 for bulk pricing.

Fibroblast Compression and Tumor Cells Migration

Role of Compression in Metastasis
Our Human Pancreatic Fibroblasts play a key role in this study.

Pancreatic fibroblasts are continuously gaining ground as an important component of tumor microenvironment that dynamically interact with cancer cells to promote tumor progression. In addition, these tumor-infiltrated fibroblasts can acquire an activated phenotype and produce excessive amounts of extracellular matrix creating a highly dense stroma, a situation known as desmoplasia. Maria Kalli, Panagiotis Papageorgis, Vasiliki Gkretsi, Triantafyllos Stylianopoulos. (2018). Solid Stress Facilitates Fibroblasts Activation to Promote Pancreatic Cancer Cell Migration. Annals of Biomedical Engineering. https://doi.org/10.1007/s10439-018-1997-7.

FIGURE 1. A schematic of the in vitro transmembrane pressure device. (a) Fibroblasts were grown as a monolayer on the transmembrane of a 0.4 lm transwell insert and a piston of adjustable weight was applying a compressive stress. Control cells were covered with an agarose cushion only. (b) The experimental set-up of the co-culture system consisted of fibroblasts and pancreatic cancer cells (MIA PaCa-2 or CFPAC-1) in the upper and lower chamber of a transwell insert, respectively. A piston with adjustable weight, applying 4.0 mmHg of compressive stress on fibroblasts for 48 h is shown. A co-culture system consisting of fibroblasts and cancer cells without a compressive load was used as a control.

FIGURE 2. Neuromics'  Human Pancreatic Fibroblast in culture-Controls and Compressed.

FIGURE 1. A schematic of the in vitro transmembrane pressure device. (a) Fibroblasts were grown as a monolayer on the transmembrane of a 0.4 lm transwell insert and a piston of adjustable weight was applying a compressive stress. Control cells were covered with an agarose cushion only. (b) The experimental set-up of the co-culture system consisted of fibroblasts and pancreatic cancer cells (MIA PaCa-2 or CFPAC-1) in the upper and lower chamber of a transwell insert, respectively. A piston with adjustable weight, applying 4.0 mmHg of compressive stress on fibroblasts for 48 h is shown. A co-culture system consisting of fibroblasts and cancer cells without a compressive load was used as a control.

Solid stress developed within tumors is able by itself to activate normal fibroblasts, which in turn produce excessive amounts of ECM proteins leading to desmoplasia.